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While important mechanistic insights were gained to decipher the glutaredoxin-catalyzed reduction of glutathione disulfide substrates, there are still major gaps in our understanding of the enzyme mechanism regarding the reduction of non-glutathione disulfide substrates

Nature 520 , 5762 (2015)

Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep

While these findings are encouraging, its important for our patients to understand that robust human clinical trials are still lacking

Such tailored intervals would significantly enhance the clinical utility of laboratory indicators [11, 12]

doi: 10.1021/bi049662h