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Nucleotides containing 8-hydroxyguanine can corrupt both DNA and RNA, causing replication and transcription errors (Yanagawa et al., 1992)

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In multiple sclerosis (MS), reactive astrocytes similarly surround the lesions, form borders and support the formation of fibrotic scar, although astrocytes present asthenia and loss of homeostatic functions 187,188

These mutations can impact folate metabolism, methylation, and homocysteine levels, influencing overall health

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