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A temporary Yap1-Gpx3 disulfide intermediate is formed when this sulfonic acid reacts with Yap1 Cys598

The search strategy employed a combination of the following keywords and MeSH terms: Parkinsons disease, ferroptosis,lipid peroxidation, alpha-synuclein, microglia, astrocytes, therapeutics, and neuroprotection. The inclusion criteria focused on original research articles, reviews, and clinical trials published in English that elucidated molecular mechanisms, pathological features, or therapeutic strategies related to ferroptosis in PD