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Hypoxia-inducible factor-1 (HIF-1) also exhibits dual regulation: during acute hypoxia, it stimulates eNOS expression to ensure adequate NO production but may suppress eNOS in chronic hypoxia, causing maladaptive vascular changes (McQuillan et al., 1994

Oxidative stress has also been reported to be involved in nephrotoxicity of some pesticides, including diazinon, acephate, and paraquat

Cell experiments 4.5.1

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