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Activated TNF-/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

however, when complications occur, such as the rupture of an atherosclerotic plaque, it can lead to myocardial infarction, stroke, peripheral vascular disease, and other high-fatality conditions

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He L, Wang Y, Curry JL, Ning J, Aung P, Nagarajan P, Prieto VG, Torres-Cabala CA , Cho WC

Biochimica et Biophysica Acta, 1826 (2), 370384

This process is essentially a combination of two direct displacement (\(S_N2\)-like) events, with sulfur atoms acting as nucleophile, electrophile and leaving group