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These events not only directly trigger chondrocyte death and extracellular matrix degradation but also exacerbate bone metabolic imbalance through intricate signaling networks

10.3390/microorganisms13030527 65 FirminoJ

In the end, it ameliorated myocardial function in diabetic mice

Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system This study aimed to assess the effects of short-term GW501516 administration on pro-inflammatory markers in white adipose tissue (WAT) and hepatic stellate cells (HSCs), as well as liver lipogenesis and insulin resistance in response to high-fructose diet (HFru)-induced ACE/AT1r axis activation

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