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It can happen if fluid builds up in the space where the tissue was removed

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Genomic Classification Cutaneous melanoma The Cancer Genome Atlas (TCGA) Network performed an integrative multiplatform characterization of 333 cutaneous melanomas from 331 patients.[1] Using six types of molecular analysis at the DNA, RNA, and protein levels, the researchers identified four major genomic subtypes: BRAF -altered

Some cases represent epidermotropic adenocarcinomas, but, unlike mammary cases (in which an underlying ductal carcinoma is almost invariably present), an underlying carcinoma is only rarely detected

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[PUBMED Abstract] Avril MF, Aamdal S, Grob JJ, et al.: Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study