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12 , e008054 (2024)

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The first was conducted by researchers from the John Hopkins Bloomberg Public School of Health, and the other was run by researchers at the University of Barcelona

Combined sample size is roughly 30 patients

The results of a functional analysis suggested reduced activity of mitochondrial Mn-dependent superoxide dismutase (MnSOD2) and impaired respiratory chain function 215

In one aspect, this invention provides a method for obtaining an immunomodulatory polynucleotide that has an optimized modulatory effect on an immune response, or encodes a polypeptide that has an optimized modulatory effect on an immune response, the method comprising: creating a library of non-stochastically generated progeny polynucleotides from a parental polynucleotide set