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On observa que les patients souffrant danmie pernicieuse amlioraient leur tat avec la consommation de foie, puis avec ladministration dextraits concentrs issus de foies animaux, qui furent utiliss pendant des annes comme traitement de rfrence, jusqu ce quon identifie la vitamine B12 comme llment actif responsable de ces effets, ce qui permit de dvelopper sa synthse isole, ralise vers le milieu du XXe sicle

100,101 As mentioned above, unlike the lung microbiome, the oropharyngeal and gut microbiomes are stable and robust, with a profound impact on the physiological and pathological state of the organism

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Curr Eye Res 1982-83;2:10:673-81