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This is supported by the RCT studies which showed a similar number of AEs in the placebo group to the treatment groups (Sandborn et al .,

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In clinical practice, combination approaches are increasingly common

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In vivo , findings demonstrate that the overexpression of indoleamine 2,3-dioxygenase (IDO) restricts ATP production in CD8+ cells, whilst in vitro studies indicate this effect is mediated by reduced activity of electron transport chain complex I, which accounts for the decreased ATP production observed in infiltrating T cells (Liu et al., 2009)

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