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Despite extensive research, most therapeutic candidates fail to achieve sufficient CNS exposure due to the restrictive bloodbrain barrier (BBB), which blocks over 98% of small molecules and nearly all biologics from entering the brain parenchyma

In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]

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Additionally, curcumin stimulated the activation of MAPK pathway which in turn induced the expression of heterodimers of NF-E2-related factors 2 (Nrf2) that is responsible for ARE activation reporter genes [268]

2005 Aug 1;579(19):4081-7

5-Fluorouracil-resistant CD34+ cell population from peripheral blood of CML patients contains BCR-ABL-negative progenitor cells