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marginale was higher due to the high prevalence of this agent (67.1%) in Mexico ( Newborn calves, adequately fed with colostrum, supplemented with selenium, iron and vitamin E throughout the suckling phase, can have an improved health status in this critical phase, since these nutrients support immune system activity, reduce the incidence of diseases, and consequently improve performance

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This necessitates either intrathecal delivery to bypass the bloodbrain barrier or systemic administration of therapies capable of crossing the bloodbrain barrier to reach the entire brain

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