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Membrane pore formation via GSDMD oligomerization was induced in meningioma cells after 8803 treatment, thereby allowing release of damage-associated molecular patterns (DAMPs) that synergistically activate local immune populations and result in upregulation of collagen-degrading genes

Nature 466 , 627631 (2010)

Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis

Moreover, a combination of 1 H- 1 H and 1 H- 13 C experiments confirmed the linkage positions, sequence and structure of the octasaccharide core with 5-linked Kdo present at the reducing end in its native structure: -Glc p NAc-(12)--Glc p -(12)--Gal p -(13)-[-Gal p -(16)]--Glc p -(13)-[-Hep p -(17)]--Hep p -(13)--Hep p -(15)-Kdo

These ELISA positive clones may also be further characterized by techniques known in the art, such as, for example, epitope mapping, binding affinity, receptor signal transduction, ability to block or competitively inhibit antibody/antigen binding, and competitive agonistic or antagonistic activity

Furthermore, in the event of a significant cardiac event such as a transient ischemic attack or myocardial infarction, normal levels of NAD+ help in the recovery from injury