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Through analyzing the PPI network, we screened hub genes APP, HSP90AA1, CAND1, CUL1, HSP90AB1, SIRT7, SRC, CDKN1A, ISG15 and RPS16 by the Cytoscape software

Similarly, it was found that the combination of inhibitors targeting PI3K/AKT/mTOR signaling pathway and atRA can almost eliminate cellular MYC to drastically kill leukemia cells of different AML subtypes (68)