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It is generally recommended to start with a dose of 500 mg per day and gradually increase it if necessary

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doi: 10.3389/fimmu.2023.1190379 Summary Keywords tremelimumab, durvalumab, ipilimumab, nivolumab, immune checkpoint inhibitor, FAERS, adverse event Citation Li Z, Xie Y, Wang T, Liu Y, Tian Y and Hua Y (2025) Evaluating the toxicity profile of combination immune checkpoint inhibitors: a disproportionality analysis of real-world adverse events from the FDA Adverse Event Reporting System for tremelimumab, durvalumab, ipilimumab, and nivolumab

When exposed to a lethal treatment, this heterogeneity may lead to the determination or selection of cells with a survival advantage, transitioning them into a DTP state 42,49

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