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The clonal evolution model suggests that cumulative genetic and epigenetic alterations drive tumor progression, whereas the cancer stem cell model posits that a subset of tumor-initiating cells sustains growth and therapeutic resistance

M., Lewkowicz, E

Folding the mitochondrial UPR into the integrated stress response

Animal studies have observed the effect of DSIP on neurotransmitter levels, circadian and locomotor patterns, hormonal levels, and psychological performance, including the withdrawal of neuropharmacological drugs