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These familial forms are linked to mutations in over 20 genes, most notably C9ORF72, Cu/Zn superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma, many of which converge on pathways critical for RNA metabolism and protein homeostasis [310,313]

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Principal Investigator on A Randomized, Double-blind, Multicentre, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy. Principal Investigator on A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNR. (Janssen)

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doi: 10.1016/j.abb.2019.07.024 52 PoloczanskaE

This analysis is based on primary and secondary research conducted through Q4 2025, with data verified as of May 2026