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One class of genes, informational genes (genes primarily involved in translation, transcription, replication, etc.), is a deeply diverging lineage which has been transferred in a tree-like pattern

In the case of GLYII proteins, two different subfamilies were observed in the phylogenetic tree, those with conserved active site motifs and therefore, enzymatically active and the other comprising of proteins which did not show conservation of active site residues

doi: 10.1038/s41590-018-0156-5 16 PearceEJEvertsB

However, these charts are not definitive equivalents

10.3390/cells12010090 435 SunZ.TangZ.YangX.LiuQ

3.2.6 Redox crosstalk among HSCs, Kupffer cells, and hepatocytes Fibrosis is a multicellular process coordinated through oxidative intercellular communication