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Cross-links formed by the interactions of AGEs with their cell surface receptors for advanced glycation end products (RAGEs) have been found during the development and progression of various aging-related diseases, such as diabetes, cardiovascular complications, kidney malfunctions, osteoporosis, cancer, neurodegenerative diseases, and liver disorders 4,5 Alcohol (ethanol), one of the most addictive substances consumed by billions of people, has been found to cause more than 200 diseases and injuries worldwide 6,7

Arsenic can also decrease vascular relaxation capacity under in vitro conditions, thus affecting smooth muscle cells (Lee et al

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Sies, H., Oxidative stress: A concept in redox biology and medicine, Redox Biol ., 2015, vol