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This resistance was mitigated by transiently transfecting NRF2 siRNA or stably overexpressing KEAP1 in both in vitro and xenograft models (107)

However, these approaches often have side effects, for example, sedation, anticholinergic effects, metabolic alterations, weight gain, and involuntary movements, and do not target the pathology or the main symptoms of ASD (27)

doi: 10.1021/jf050206p

In: Lal R (ed) Encyclopedia of Soil Science, 3rd edn

Insulin-like growth factor 1, the main mediator of GH actions, is an amino acid insulinoid peptide with an amino acid sequence similar to that of proinsulin (positions 129 are homologous to insulin B chain and positions 4262 to insulin A chain)