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Several repurposed drugs are being evaluated in NSCLC: Metformin: This widely used antidiabetic drug inhibits mitochondrial complex I, reduces hepatic gluconeogenesis, and activates AMPK

The RDA The recommended dietary allowance (RDA) for riboflavin, revised in 1998, is based on the prevention of deficiency ( Table 1 )

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Thus, as the SLC1A5 variant is the only currently known glutamine transporter in the mitochondrial inner membrane 16 , targeting the SLC1A5 variant could be an effective strategy for selectively inhibiting glutamine metabolism in cancer cells (Fig