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Prolonged or repeated stress exposure has often been associated with altered cortisol dynamics and may precipitate a cascade of neurobiological changes, including increased neuroinflammatory activity, persistent oxidative stress, dysregulation of key neurotransmitter systems, and structural as well as functional abnormalities within the hippocampus

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Last reviewed: June 2026 Medical disclaimer: This article provides general information only and is not a substitute for personalised medical advice

Treatment protocols for KL Grade III and IV knees Three documented treatment tiers apply once imaging confirms an advanced KL Grade III or IV joint and the mechanical prerequisites are met

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