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Chronic fatigue syndrome

Methylglyoxal, the dark side of glycolysis

The mechanism of DNA methylation inhibition is manifested in the following two aspects

pmid:24213319

Activation of TFs in tumors due to promoter hypomethylation generally relates to the development of transcriptional regulation, including PITX1, PITX2, MSX1, MSX2 and SIM2

However, the quantities of these enzymes vary under conditions of high OS, such as sepsis, which may lead to an accumulation of harmful ROS (Andrades et al., 2005)