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Structural basis of inhibition of insulin-regulated aminopeptidase by a macrocyclic peptidic inhibitor

Weight reduction: Clinical trials report substantial bodyweight loss (up to ~11 kg more than GLP1 RA comparators over 26 weeks at higher doses) [3] [4]

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Proc Natl Acad Sci 106(51):2197221977 Coletta C et al (2012) Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation