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Comparative toxicity assessment of kratom decoction, mitragynine and speciociliatine versus morphine on zebrafish (Danio rerio) embryos

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In this pathway, NOS catalyzes the conversion of L-arginine and oxygen to L-citrulline and NO (Tousoulis et al., 2012)

10.1371/journal.ppat.1002715 33 CasrougeA.ZhangS.EidenschenkC.JouanguyE.PuelA.YangK.et al

Under certain conditions, such as when the apoptotic pathway is inhibited or under intense inflammatory signals, necroptosis may occur [16]