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Our data support a model in which Ran-GTP and RanBP1 facilitate cargo passage through the NPC and its controlled release at the NPC basket, while Ran-GDP, in conjunction with RanBP1, can bind importin and potentially sequester it in a manner that does not promote transport

Cell 172 , 952965 (2018)

Scientists just figured out (the paper was released on March 23, 2017) how to do this in mice (and very probably in humans)

However, an important caveat remains: Many of these digital signals are more reflective of symptomatic fluctuations, often influenced by medication or contextual factors, rather than direct markers of disease progression or underlying pathology