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4 Carcinogenic mechanisms of microbiota Unlike normal cells, tumor cells could coexist with specific bacteria and fungi, forming a symbiotic microbiota that benefits both tumor and microbial proliferation and drug resistance ( Aspergillus, Blastomyces, Cryptococcus, Malassezia, Candida, Bacillus , while bacteria such as Staphylococcus, Streptococcus, Pseudomonas aeruginosa (P

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In addition, patients with STK11/LKB1 mutations were resistant to PD-1 inhibitors in KRAS-mutant LAC, suggesting a new mechanism of resistance 103

Nat Rev Neurol 12:699713 Friedmann AJ, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Khalifa et al., 2024c)