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(2020) 4:e2000034

Potential implications of HS treatments on inflammation and tissue architecture Pharmacological modulation of HS: from conventional antibiotics to precision biologic interventions The management of moderate-to-severe HS increasingly relies on conventional and targeted therapies, which interrupt broad or specific inflammatory pathways to reduce disease activity, respectively

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In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation