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The disease not only imposes significant physical and emotional burdens on patients but also results in substantial socioeconomic costs

265 Leu depletion in T cells leads to restricted mTORC1 signaling and inhibits T-cell activation

The lack of consistent changes in expression of Class I alleles in human or murine PCa cells suggests that the Class I upregulation and consequent CD8-dependent immune response reported in IGF-depleted or inhibited tumors 13,19 may be due not to reduced expression of MHC -chains, but rather to disruption of peptide transport and processing, and downregulation of invariant Class I component 2M