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In some embodiments, the invention encompasses a method of providing muscular therapy by co-administering a therapeutically effective amount of one or more NNMT inhibitors with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

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"Care should be taken to avoid overdosing, particularly during early pregnancy," Ms Krilich said

Safety, Monitoring, and Contraindications Because Tesofensine influences norepinephrine and dopamine, it requires careful cardiovascular and neurological monitoring