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Mitochondrial uptake of calcium in response to excitotoxic glutamate stimulation leads to ROS production (Castilho et al., 1999)excessive opening of the mitochondrial membrane permeability transition pore leads to a decrease in mitochondrial membrane potential (Castilho et al., 1999), induction of neuronal death (Stout et al., 1998

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Research found that it lowered blood pressure and improved kidney disease markers in patients (x)