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Nanoparticles have also shown the ability to target endothelial cells, effectively delivering anti-angiogenic drugs to the tumor site and enhancing the therapeutic effect by reducing systemic toxicity (190).This therapy is still at an early stage of development and shows great potential in inhibiting tumor angiogenesis (191)

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After one week of recovery period, only the recipient mice that exceeded the initial body weight (i.e., body weight of the recipient plus weight of the transplant) were subjected to a HFD (D12451) (45.0 % kcal from fat) (Research Diets Inc.) for 8 weeks