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Additionally, while ALA has been thought to activate insulin signaling pathways to combat diabetes [28] and has been shown to prevent high fructose-induced cardiometabolic disorders and renal dysfunction [62], it has also been reported that ALA could only attenuate proteinuria and oxidative stress without slowing progression of diabetic renal failure [63]

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This persistent exposure to various inflammatory stimuli, including environmental toxins, infections, and autoimmunity, creates an inflammatory microenvironment that enhances oncogenic processes and facilitates tumor initiation [5,6,7]