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These compounds also inhibite glucokinase (GCK), pyruvate kinase (PK), and citrate synthase (CS) in the liver, further verifying the potential role of Scrophulariae Radix in regulating glucose metabolism and inhibiting excessive metabolism (103)

By integrating primary hepatocytes with non-parenchymal liver cells under continuous perfusion, the human liver-on-chip maintained long-term metabolic competence and reproduced clinically relevant mechanisms of drug-induced liver injury (DILI) at exposure levels comparable to patient plasma concentrations

Bhavana herbs like Haritaki or Bala may be preferred to stabilize the nervous system and enhance nutrient delivery without overstimulation ( 66 )