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patients with heart disease or high blood pressure should be monitored

Some peptides may stop producing noticeable effects before they are fully cleared from the body

This results in blood pooling in the lower extremities, increasing venous pressure and damaging vein valves

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However, if the dog results had been tabulated against the rat intravenous LD 50 values (Tauberger & Klimmer, 1963), cobalt histidine might have been preferred, this antidote having a much higher intravenous LD 50 than dicobalt edetate