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There is limited evidence suggesting direct effects on hormone levels

Acta 1857 , 9911000 (2016)

doi: 10.5402/2011/832560 96 RicciardoloFLM

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Since then, the idea of liver cirrhosis as a condition of IGF-I deficiency during adult age has been yearly consolidated from a number of publications establishing the origin of this lack from a decrease in GH receptors seen in cirrhotic livers[216] and a progressive reduction of liver synthesis capability from decreased hepatocellular mass in advanced stages[209]