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however, no significant delays in closure were observed on day 4 post-wounding

Copper is also critical for antioxidant enzymes, so it should come as no surprise that copper peptides like GHK-Cu affect oxidative stress and inflammation

Nat Rev Rheumatol (2009) 5(10):5727

PMID: 2555512 PMC1572913 Pigmentation Pathway (MC1R, Preclinical) Eumelanin upregulation via cAMP / MITF / tyrosinase axis MC1R activation by melanocortin agonists is reported to raise intracellular cAMP, upregulate MITF, and increase tyrosinase-mediated eumelanin synthesis in epidermal melanocyte models

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These effects appear to result from GHK-Cu's ability to enhance Schwann cell proliferation and migration while promoting the expression of myelin-associated proteins essential for nerve fiber repair