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OA chondrocytes displayed reduced mitochondrial DNA content, mitochondrial dysfunction, and diminished expression of NRF2 which regulates the transcription of oxidoreductase genes 89

Supplementary material The Supplementary Material for this article can be found online at: References 1 ArnrE

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doi: 10.1016/S0021-9258(17)40528-X 92

And study 62 shows that the studies in urban areas have shown that PM 2.5 collected from different seasons exhibits varying OP levels, influenced by factors such as traffic emissions and industrial activities 63