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During the lipid peroxidation pathway, ACSL4 promotes ferroptosis by producing oxidized PE at the endoplasmic reticulum (ER)-associated oxygenation center, and ACSL4 catalyzes the attachment of AA or adrenaline (AdA) to produce AA or AdA acyl Co-A derivatives, which is then esterified to PE (AA-PE and AdA-PE) by lysophosphatidylcholine acyltransferase 3 (LPCAT3)

Specifically, it was shown that uptake of Borrelia by macrophages is not a simple, one-directional process but rather a lengthy battle, where the back-and-forth movement of the spirochaete might create tunnels inside the macrophage [22]

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2 x 3 cm in size and which, as a result of the added system components, resulted in a pH of 8.0 to 8.5