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In the PNS, thiamine deficiency can result in polyneuritis and paralysis, as seen in dry beriberi, which affects the sensory system, causing pain, altered temperature sensitivity, numbness, reduced tendon reflexes, and leg atrophy ( Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )

Harikrishnan, K.N

A high f/f 0 is characteristic of an extended, flexible, and unfolded protein

[43] Alcohol binds to several different subtypes of GABA A , but not to others

Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study