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Given the balance between the central production of BDNF and proBDNF and their circulating levels [11], the brain production of these neurotrophins can be postulated to increase during cocaine withdrawal

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In some embodiments, the otoprotectant is D-methionine

To our knowledge, the present study was the first to report the concurrent upregulation of proBDNF and BDNF in CUD individuals, with no impact on the proBDNF/BDNF ratio

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