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Although genetic variations at these loci have long been considered neutral, the availability of a significant amount of epidemiological data and the use of mathematical models have allowed us to discover that some combinations of alleles at these loci may be subject to selection and that some combinations in some hypervirulent lines are associated with small gains in fitness for meningococcal transmission (Stollenwerk et al., 2004

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Reproduction studies of acetylcysteine with isoproterenol have been performed in rats and of acetylcysteine alone in rabbits at doses up to 2.6 times the human dose