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doi: 10.1038/s41467-020-15109-y 30 PerroneMCarocciaNGenoveseIMissiroliSModestiLPedrialiGet al

The slightly greater HMOX1 induction by heme compared with heme-HPX is because the rate of heme diffusion into cells is significantly faster than the gradual, relatively slow and safe heme delivery via heme-HPX endocytosis (Smith and Morgan, 1981)

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Transcriptional Control: One of the primary modes of regulation of the mevalonate pathway is through the transcriptional regulation of key enzymes

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