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Two-thirds of the patients reported significant clinical improvement, which was objectively accompanied by an increased number of daily steps and improved scores on validated physical functioning and fatigue scales

This muscle-sparing effect distinguishes it from many other fat loss approaches including some GLP-1 medications and severe caloric restriction

It is prominently expressed in the central nervous system and is implicated in activity-dependent synaptic plasticity

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Experimental studies on gastric cancer cell lines CUM-2MD3 and OCUM-12 have found that under hypoxic conditions, GC cells form EMT through autocrine stimulation of TGF factors (172)