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The metabolic drug product or metabolite produced following phase I modifications can also act as a substrate for additional modifications, such as phase II conjugation reactions

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sepsis and respiratory failure (1% each)

The diversity of the molecules metabolized by these enzymes is a defining feature, and a single CYP has the potential to metabolize multiple different drugs

Administration of a GSH inhibitor into nucleus accumbens impairs PR test performance To assess whether decreasing local accumbal GSH levels alters motivated performance, rats were injected with either BSO (an inhibitor of gamma-glutamylcysteine synthetase-the rate-limiting enzyme for GSH synthesis) at 7 g/l or DMSO (the diluent of BSO) intra-NuAc (1 l per hemisphere) (Figure 4a and 4b)

In disorders such as thalassemia and sickle cell anemia, this is clearly visible