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Results Cryo-EM structure of importin bound to IBBs and FG-nup Molecular dynamics simulations 41,45,46,47,48 , Frster resonance energy transfer 48 , small-angle X-ray scattering 46 , crystallographic 35,39,40,49 , and biochemical 50 data provided compelling evidence that importin undergoes large structural fluctuations during nuclear transport