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2017;63:e12438

J.MahadevanA.PhilipM.ParmarS

Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function

Increased levels of Irisin (1 mg/kg/day, 5 days/week, 2 weeks) could significantly mitigate ROS accumulation, dysregulation of autophagy, NF-B-Snail pathway activation, and the phenotype of endothelial-to-mesenchymal transition through targeting UCP2 in a mouse DIC model [140]

Variability in study designs and patient cohortsoften excluding early-stage CKD or non-dialysis populationsfurther obscures the generalizability of findings (121)

Casto, Sean C