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Muller C, Salvayre R, Negre-Salvayre A, Vindis C

The study published by Misbach et al dedicated to the establishment of echocardiographic reference intervals in a large population of healthy CKCSs also demonstrated the discrepancy between their LV breed-specific reference intervals (assessed according to the Clinical Laboratory and Standard Institute recommendations) and the predictive reference intervals obtained in the same population using Cornell's formula." "Regarding LA size, CKCS dogs seem to have smaller end-diastolic and end-systolic LA dimensions than most other breeds." "Based on these data, the end-systolic LA:Ao ratio cut-off value of 1.6 proposed by the 2019 consensus ACVIM statement to detect end-systolic LA enlargement in all-breed dogs appears inappropriate (i.e., too high) for CKCSs, with a risk of missing some mild LA dilations." "[A] sub-population [31 -- 37%] of ACVIM B1 dogs with normal LA/Ao ratios actually showed LA dilation detected by LA volume calculation, which was not apparent when applying end-diastolic and end-systolic LA:Ao ratios." "Additionally, among the 31 CKCSs with normal end-systolic LA:Ao ratio but increased LASvol/BW volume (Fig 3), 19/31 (61%) showed increased end-diastolic LV diameter

& Lushchak, V

& Mansouri, K

The use of antisense oligonucleotide volanesorsen targeting ApoC3 could reduce the bone erosion area in CIA model by 63% (81)