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The resulting chain reaction leads to the peroxidation of the mitochondrial and plasma membranes

1:500 (v/v) added to the methanol and used for standardization of the metabolite intensity and to adjust the migration time), and were scraped from the dish

Calcitriol can affect neuroplasticity, apoptosis, and gene expression (such as neurotransmitters, neurotrophic, and synaptic proteins) (102)

5 Conclusion Collectively, it can be concluded that MTX-induced hepatotoxicity is mediated, at least in part, through ER stress, which was confirmed by the reversal of MTX toxicity upon administration of 4-PBA and NAC