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Cytokine Growth Factor Rev 22:189195

doi:10.1002/14651858.CD012614.pub2

In addition, this combination not only inhibits inhibitor of nuclear factor kappa B (NF-B) phosphorylation, thereby reducing nuclear translocation of NF-B and suppressing downstream inflammatory cytokine expression (TNF- and ICAM-1 mRNA) within the NF-B signaling pathway but also mitigates phosphorylation of Janus Kinase 1 (JAK1) and signal transducer and activator of transcription 1 (STAT1), suppressing activation of the JAK1/STAT1 pathway to enhance inflammatory response inhibition post-cerebral ischemia

If inflammation is not controlled, it can affect deeper layers of the skin

Antimalarial drugs that can cause acute hemolysis in people with G6PD deficiency include primaquine and tafenoquine

This makes it unique among the compounds discussed here, because it delivers a broad spectrum of neurotrophic factors rather than a single targeted signal